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A chimeric, half-life extended lysin with a unique mode of action

2026-05-15

Abstract excerpt

Anti-staphylococcal lytic agents, such as lysostaphin (LSN), a glycyl-glycyl (Gly-Gly) peptidase, have long been considered for the management of chronic and complicated bacterial infections typically resistant to conventional antibiotics, but their use is restricted by poor pharmacokinetic properties. We generated half-life extended lysostaphin constructs by fusing the lysin - either alone or chimerized with an a...

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Identifiers and source

Literature Corpus work
cb7e27d5-91a1-5880-90a4-a7ccfbc8fd83
DOI
10.64898/2026.05.13.724763
Open publication

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A chimeric, half-life extended lysin with a unique mode of actionDOI 10.64898/2026.05.13.724763
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