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Article

InVivo Dissection of the Intrinsically Disordered Receptor Domain of Tim23.

Journal of molecular biology - 1 May 2020

Günsel Umut, Paz Eyal, Gupta Ruhita, Mathes Isabella, Azem Abdussalam, Mokranjac Dejana

Abstract excerpt

In the intermembrane space (IMS) of mitochondria, the receptor domain of Tim23 has an essential role during translocation of hundreds of different proteins from the cytosol via the TOM and TIM23 complexes in the outer and inner membranes, respectively. This intrinsically disordered domain, which can even extend into the cytosol, was shown, mostly in vitro, to interact with several subunits of the TOM and TIM23...

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Identifiers

PMID: 32277989
DOI: 10.1016/j.jmb.2020.03.031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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InVivo Dissection of the Intrinsically Disordered Receptor Domain of Tim23.PMID 32277989Read ↗

The role of the TIM8-13 complex in the import of Tim23 into mitochondria.Semantic proximity Read ↗

Role of Tim17 Transmembrane Regions in Regulating the Architecture of Presequence Translocase and Mitochondrial DNA Stability.Semantic proximity Read ↗

Hotspots for Disease-Causing Mutations in the Mitochondrial TIM23 Import Complex.Semantic proximity Read ↗

Biogenesis of Tim Proteins of the Mitochondrial Carrier Import Pathway: Differential Targeting Mechanisms and Crossing Over with the Main Import PathwaySemantic proximity Read ↗

A presequence- and voltage-sensitive channel of the mitochondrial preprotein translocase formed by Tim23.Semantic proximity Read ↗

Interaction of Tim23 with Tim50 Is essential for protein translocation by the mitochondrial TIM23 complex.Semantic proximity Read ↗

Biogenesis of Tim23 and Tim17, integral components of the TIM machinery for matrix‐targeted preproteinsSemantic proximity Read ↗

The channel-forming Sym1 protein is transported by the TIM23 complex in a presequence-independent manner.Semantic proximity Read ↗

Reduced Protein Import via TIM23 SORT Drives Disease Pathology in TIMM50-Associated Mitochondrial Disease.Semantic proximity Read ↗

Cation selectivity of the presequence translocase channel Tim23 is crucial for efficient protein import.Semantic proximity Read ↗

Two distinct membrane potential-dependent steps drive mitochondrial matrix protein translocation.Semantic proximity Read ↗

OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocaseSemantic proximity Read ↗

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