Cation selectivity of the presequence translocase channel Tim23 is crucial for efficient protein import.

doi:10.7554/eLife.28324

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Cation selectivity of the presequence translocase channel Tim23 is crucial for efficient protein import.

eLife - 31 Aug 2017

Denkert Niels, Schendzielorz Alexander Benjamin, Barbot Mariam, Versemann Lennart, Richter Frank, Rehling Peter, Meinecke Michael

Abstract excerpt

Virtually all mitochondrial matrix proteins and a considerable number of inner membrane proteins carry a positively charged, N-terminal presequence and are imported by the TIM23 complex (presequence translocase) located in the inner mitochondrial membrane. The voltage-regulated Tim23 channel constitutes the actual protein-import pore wide enough to allow the passage of polypeptides with a secondary structure. In...

Topics

Amino Acid Motifs
Binding Sites
Biological Transport
Cardiolipins
Cloning, Molecular
Escherichia coli
Gene Expression
Genetic Vectors
Kinetics
Membrane Potential, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Transport Proteins

Mitochondria

Mitochondrial Precursor Protein Import Complex Proteins

Mutation

Phosphatidylcholines

Phosphatidylethanolamines

Phosphatidylinositols

Phosphatidylserines

Source

Open in PubMed Open full text

Identifiers

PMID: 28857742
DOI: 10.7554/eLife.28324
PMCID: PMC5578737

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cation selectivity of the presequence translocase channel Tim23 is crucial for efficient protein import.PMID 28857742Read ↗

A presequence- and voltage-sensitive channel of the mitochondrial preprotein translocase formed by Tim23.Semantic proximity Read ↗

Role of Tim17 Transmembrane Regions in Regulating the Architecture of Presequence Translocase and Mitochondrial DNA Stability.Semantic proximity Read ↗

Hotspots for Disease-Causing Mutations in the Mitochondrial TIM23 Import Complex.Semantic proximity Read ↗

InVivo Dissection of the Intrinsically Disordered Receptor Domain of Tim23.Semantic proximity Read ↗

The channel-forming Sym1 protein is transported by the TIM23 complex in a presequence-independent manner.Semantic proximity Read ↗

The role of the TIM8-13 complex in the import of Tim23 into mitochondria.Semantic proximity Read ↗

Reduced Protein Import via TIM23 SORT Drives Disease Pathology in TIMM50-Associated Mitochondrial Disease.Semantic proximity Read ↗

Two distinct membrane potential-dependent steps drive mitochondrial matrix protein translocation.Semantic proximity Read ↗

Biogenesis of Tim Proteins of the Mitochondrial Carrier Import Pathway: Differential Targeting Mechanisms and Crossing Over with the Main Import PathwaySemantic proximity Read ↗

Mitochondrial protein import motor: differential role of Tim44 in the recruitment of Pam17 and J-complex to the presequence translocase.Semantic proximity Read ↗

Identification of MIM23, a putative component of the protein import machinery of the mitochondrial inner membrane.Semantic proximity Read ↗

Biogenesis of Tim23 and Tim17, integral components of the TIM machinery for matrix‐targeted preproteinsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.