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Article

Cation selectivity of the presequence translocase channel Tim23 is crucial for efficient protein import.

eLife - 31 Aug 2017

Denkert Niels, Schendzielorz Alexander Benjamin, Barbot Mariam, Versemann Lennart, Richter Frank, Rehling Peter, Meinecke Michael

Abstract excerpt

Virtually all mitochondrial matrix proteins and a considerable number of inner membrane proteins carry a positively charged, N-terminal presequence and are imported by the TIM23 complex (presequence translocase) located in the inner mitochondrial membrane. The voltage-regulated Tim23 channel constitutes the actual protein-import pore wide enough to allow the passage of polypeptides with a secondary structure. In...

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Identifiers

PMID: 28857742
DOI: 10.7554/eLife.28324
PMCID: PMC5578737

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cation selectivity of the presequence translocase channel Tim23 is crucial for efficient protein import.PMID 28857742Read ↗

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