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Article

Role of Tim17 Transmembrane Regions in Regulating the Architecture of Presequence Translocase and Mitochondrial DNA Stability.

Molecular and cellular biology - 15 Mar 2017

Matta Srujan Kumar, Pareek Gautam, Bankapalli Kondalarao, Oblesha Anjaneya, D'Silva Patrick

Abstract excerpt

Mitochondrial life cycle and protein import are intricate cellular processes, which require precise coordination between the transport machineries of outer and inner mitochondrial membranes. Presequence translocase performs the indispensable function of translocating preproteins having N-terminal targeting sequences across the inner membrane. Tim23 forms the core of the voltage-gated import channel, while Tim17...

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Source

Open in PubMed Open full text

Identifiers

PMID: 27994013
DOI: 10.1128/MCB.00491-16
PMCID: PMC5335507

Genes

PAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Role of Tim17 Transmembrane Regions in Regulating the Architecture of Presequence Translocase and Mitochondrial DNA Stability.PMID 27994013Read ↗

A presequence- and voltage-sensitive channel of the mitochondrial preprotein translocase formed by Tim23.Semantic proximity Read ↗

The channel-forming Sym1 protein is transported by the TIM23 complex in a presequence-independent manner.Semantic proximity Read ↗

Hotspots for Disease-Causing Mutations in the Mitochondrial TIM23 Import Complex.Semantic proximity Read ↗

InVivo Dissection of the Intrinsically Disordered Receptor Domain of Tim23.Semantic proximity Read ↗

The divergent N-terminal domain of Tim17 is critical for its assembly in the TIM complex in Trypanosoma brucei.Semantic proximity Read ↗

Cation selectivity of the presequence translocase channel Tim23 is crucial for efficient protein import.Semantic proximity Read ↗

Pam17 and Tim44 act sequentially in protein import into the mitochondrial matrix.Semantic proximity Read ↗

Mitochondrial protein import motor: differential role of Tim44 in the recruitment of Pam17 and J-complex to the presequence translocase.Semantic proximity Read ↗

The role of the TIM8-13 complex in the import of Tim23 into mitochondria.Semantic proximity Read ↗

Expression of the human TIMM23 and TIMM23B genes is regulated by the GABP transcription factor.Semantic proximity Read ↗

OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocaseSemantic proximity Read ↗

Biogenesis of Tim Proteins of the Mitochondrial Carrier Import Pathway: Differential Targeting Mechanisms and Crossing Over with the Main Import PathwaySemantic proximity Read ↗

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