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Article

Generation of Hoxc13 knockout pigs recapitulates human ectodermal dysplasia-9.

Human molecular genetics - 1 Jan 2017

Han Kai, Liang Liuping, Li Li, Ouyang Zhen, Zhao Bentian, Wang Qi, Liu Zhaoming, Zhao Yu, Ren Xiaoshuai, Jiang Fei, Lai Chengdan, Wang Kepin, Yan Sen, Huang Liang, Guo Lin, Zeng Kang, Lai Liangxue, Fan Nana

Abstract excerpt

Atrichia and sparse hair phenotype cause distress to many patients. Ectodermal dysplasia-9 (ED-9) is a congenital condition characterized by hypotrichosis and nail dystrophy without other disorders, and Hoxc13 is a pathogenic gene for ED-9. However, mice carrying Hoxc13 mutation present several other serious disorders, such as skeletal defects, progressive weight loss and low viability. Mouse models cannot...

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PMID: 28011715
DOI: 10.1093/hmg/ddw378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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