Article
Limb malformations and the human HOX genes.
American journal of medical genetics - 15 Oct 2002
Goodman Frances R
Abstract excerpt
HOX genes encode a family of transcription factors of fundamental importance for body patterning during embryonic development. Humans, like most vertebrates, have 39 HOX genes organized into four clusters, with major roles in the development of the central nervous system, axial skeleton, gastrointestinal and urogenital tracts, external genitalia, and limbs. The first two limb malformations shown to be caused by...
Topics
- Animals
- Foot Deformities, Congenital
- Gene Deletion
- Genes, Homeobox
- Genes, Regulator
- Genitalia
- Genome, Human
- Hand Deformities, Congenital
- Homeodomain Proteins
- Humans
- Limb Deformities, Congenital
- Mice
- Multigene Family
- Mutation
- Phenotype
- Polydactyly
- Syndactyly
- Syndrome