Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Understanding the molecular mechanisms of human microtia via a pig model of HOXA1 syndrome.

Disease models & mechanisms - 1 Jun 2015

Qiao Ruimin, He Yuyong, Pan Bo, Xiao Shijun, Zhang Xufei, Li Jing, Zhang Zhiyan, Hong Yuan, Xing Yuyun, Ren Jun

Abstract excerpt

Microtia is a congenital malformation of the outer ears. Although both genetic and environmental components have been implicated in microtia, the genetic causes of this innate disorder are poorly understood. Pigs have naturally occurring diseases comparable to those in humans, providing exceptional opportunity to dissect the molecular mechanism of human inherited diseases. Here we first demonstrated that a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms
Share to Crosses, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Recessive

Share to Genetic Loci

Share to Homeodomain Proteins

Share to Inheritance Patterns

Share to Sus scrofa

Share to Syndrome

Source

Open in PubMed Open full text

Identifiers

PMID: 26035869
DOI: 10.1242/dmm.018291
PMCID: PMC4457031

Genes

HOXA1
EVC2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Understanding the molecular mechanisms of human microtia via a pig model of HOXA1 syndrome.PMID 26035869Read ↗

Whole genome resequencing reveals an association of ABCC4 variants with preaxial polydactyly in pigsSemantic proximity Read ↗

A joint analysis using exome and transcriptome data identifiescandidate polymorphisms and genes involved with umbilical hernia in pigs.Semantic proximity Read ↗

Genes and SNPs Involved with Scrotal and Umbilical Hernia in Pigs.Semantic proximity Read ↗

Whole-exome sequencing analysis in 10 families of sporadic microtia with thoracic deformities.Semantic proximity Read ↗

A 76-base pair duplication within the enhancer region of the HMX1 gene causes sheep microtia.Semantic proximity Read ↗

Genetic structure and domestication footprints of the tusk, coat color, and ear morphology in East Chinese pigs.Semantic proximity Read ↗

Transcriptome analysis identifies genes involved with the development of umbilical hernias in pigs.Semantic proximity Read ↗

JAG2: A Potential Biomarker for Microtia Identified by Integrated RNA Transcriptome AnalysisSemantic proximity Read ↗

Genome-wide association study shows that microtia in Altay sheep is caused by a 76 bp duplication of HMX1.Semantic proximity Read ↗

Transcript Profiles of Stria Vascularis in Models of Waardenburg Syndrome.Semantic proximity Read ↗

A missense mutation in PPARD causes a major QTL effect on ear size in pigs.Semantic proximity Read ↗

Genome-wide association studies and meta-analysis reveal novel quantitative trait loci and pleiotropic loci for swine head-related traits.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.