Article

Beyond Excitotoxicity: Glutamate-Independent Mechanisms Underlie Noise-Induced Synaptopathy and Compromise Gene Therapy for Hereditary Deafness

2026-05-21

Abstract excerpt

<title>Abstract</title> <p> Noise-induced hearing loss (NIHL) is classically attributed to glutamate excitotoxicity, yet the precise requirement for synaptic glutamate release remains untested using genetic approaches. Here, we investigated noise-induced cochlear damage using <italic>Vglut3</italic> knockout ( <italic>Vglut3</italic> -KO) mice, which lack glutamatergic transmission from inner hair cells. Fol...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8b82d784-a8f7-5a5f-9e46-80d2814634b4
DOI: 10.21203/rs.3.rs-9626899/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Beyond Excitotoxicity: Glutamate-Independent Mechanisms Underlie Noise-Induced Synaptopathy and Compromise Gene Therapy for Hereditary DeafnessDOI 10.21203/rs.3.rs-9626899/v1Read

Orphan glutamate receptor delta1 subunit required for high-frequency hearing.Semantic proximity Read

VGLUT3-p.A211V variant fuses stereocilia bundle and elongates synaptic ribbons in the human deafness DFNA25Semantic proximity Read

Mutation of Foxo3 causes adult onset auditory neuropathy and alters cochlear synapse architecture in mice.Semantic proximity Read

Impairment of SLC17A8 encoding vesicular glutamate transporter-3, VGLUT3, underlies nonsyndromic deafness DFNA25 and inner hair cell dysfunction in null mice.Semantic proximity Read

Characterizing a novel vGlut3-P2A-iCreER knockin mouse strain in cochlea.Semantic proximity Read

ATP1A3 mutations can cause progressive auditory neuropathy: a new gene of auditory synaptopathy.Semantic proximity Read

Signaling in the Auditory System: Implications in Hair Cell Regeneration and Hearing Function.Semantic proximity Read

Contrasting mechanisms for hidden hearing loss: synaptopathy vs myelin defectsSemantic proximity Read

Molecular Aspects of the Development and Function of Auditory Neurons.Semantic proximity Read

miR-431 secreted by human vestibular schwannomas increases the mammalian inner ear’s vulnerability to noise traumaSemantic proximity Read

A mutation in synaptojanin 2 causes progressive hearing loss in the ENU-mutagenised mouse strain Mozart.Semantic proximity Read

Endogenous SIRT3 activity is dispensable for normal hearing recovery after noise exposure in young adult miceSemantic proximity Read