Article
Validation of a genome-wide association study implied that SHTIN1 may involve in the pathogenesis of NSCL/P in Chinese population.
Scientific reports - 23 Dec 2016
Wang Yirui, Sun Yimin, Huang Yongqing, Pan Yongchu, Yin Aihua, Shi Bing, Du Xuefei, Ma Lan, Lan Feifei, Jiang Min, Shi Jiayu, Zhang Lei, Xiao Xue, Zhou Zhongwei, Jiang Hongbing, Wang Lin, Yang Yinxue, Cheng Jing
Abstract excerpt
Orofacial clefts are among the most common birth defects in humans worldwide. A large-scale, genome-wide association study (GWAS) in the Chinese population recently identified several genetic risk variants for nonsyndromic cleft lip with or without cleft palate (NSCL/P). We selected 16 significant SNPs from the GWAS I stage (P < 1.00E-5) that had not been replicated to validate their association with NSCL/P in...
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