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Article

Evaluating the Role of VAX1, MAFB, and NOG in Non-Syndromic Cleft Palate Only Among Japanese Individuals.

Congenital anomalies - 1 Jan 2026

Thao Tran Phuong, Niimi Teruyuki, Anh Le Kha, Suzuki Satoshi, Hayakawa Toko, Kitagawa Ken, Imura Hideto, Kondo Hisataka, Furukawa Hiroo, Natsume Nagana, Natsume Nagato

Abstract excerpt

Non-syndromic cleft palate only (NSCPO) is a distinct clinical and etiological entity within the spectrum of orofacial clefts. While genome-wide association studies (GWAS) have identified numerous risk loci for nonsyndromic cleft lip with or without cleft palate (NSCL/P), the genetic architecture of NSCPO remains less understood, particularly in the Japanese population. This study aimed to investigate the...

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Source

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Identifiers

PMID: 42527986
DOI: 10.1002/cga.70071
PMCID: PMC13420969

Genes

VAX1
MAFB
NOG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Evaluating the Role of VAX1, MAFB, and NOG in Non-Syndromic Cleft Palate Only Among Japanese Individuals.PMID 42527986Read ↗

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VAX1 gene associated non-syndromic cleft lip with or without palate in Western Han Chinese.Semantic proximity Read ↗

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Different roles of two novel susceptibility loci for nonsyndromic orofacial clefts in a Chinese Han population.Semantic proximity Read ↗

An Association Study of Candidate Gene Variants in Chinese Nonsyndromic Cleft Lip with or without Palate SubjectsSemantic proximity Read ↗

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The potential up-regulation risk of 3' UTR SNP (rs10787760 G > A) for the VAX1 gene is associated with NSCLP in the northwest Chinese population.Semantic proximity Read ↗

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Replication of genome wide association identified candidate genes confirm the role of common and rare variants in PAX7 and VAX1 in the etiology of nonsyndromic CL(P).Semantic proximity Read ↗

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