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Article

Mendelian randomization estimates of alanine aminotransferase with cardiovascular disease: Guangzhou Biobank Cohort study.

Human molecular genetics - 15 Jan 2017

Xu Lin, Jiang Chao Qiang, Lam Tai Hing, Zhang Wei Sen, Zhu Feng, Jin Ya Li, Thomas G Neil, Cheng Kar Keung, Schooling C Mary

Abstract excerpt

Observational studies of the association of alanine aminotransferase (ALT) levels with ischaemic heart disease (IHD) and cardiovascular disease (CVD) risk factors are inconsistent, probably because of confounding and reverse causality. Mendelian randomization (MR) provides less confounded results. We used MR analysis to assess the associations of ALT (U/L) with IHD, diabetes and other CVD risk factors. We used...

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Identifiers

PMID: 28007909
DOI: 10.1093/hmg/ddw396

Genes

MAPK10
PNPLA3
SAMM50

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