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Article

Mitochondrial mislocalization and altered assembly of a cluster of Barth syndrome mutant tafazzins.

The Journal of cell biology - 31 Jul 2006

Claypool Steven M, McCaffery J Michael, Koehler Carla M

Abstract excerpt

None of the 28 identified point mutations in tafazzin (Taz1p), which is the mutant gene product associated with Barth syndrome (BTHS), has a biochemical explanation. In this study, endogenous Taz1p was localized to mitochondria in association with both the inner and outer mitochondrial membranes facing the intermembrane space (IMS). Unexpectedly, Taz1p does not contain transmembrane (TM) segments. Instead, Taz1p...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16880272
DOI: 10.1083/jcb.200605043
PMCID: PMC2064234

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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