Article
Multiplex Identification of Human Papillomavirus 16 DNA Integration Sites in Cervical Carcinomas
18 Jun 2013
Abstract excerpt
Cervical cancer is caused by high-risk human papillomaviruses (HPV), in more than half of the worldwide cases by HPV16. Viral DNA integration into the host genome is a frequent mutation in cervical carcinogenesis. Because integration occurs into different genomic locations, it creates unique viral-cellular DNA junctions in every single case. This singularity complicates the precise identification of HPV...
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