Article
CD14++ CD16- monocytes are the main source of 11β-HSD type 1 after IL-4 stimulation.
International immunopharmacology - 1 Feb 2017
Kunnathully Vidya, Gomez-Lira Macarena, Bassi Giulio, Poli Fabio, Zoratti Elisa, La Verde Valentina, Idolazzi Luca, Gatti Davide, Viapiana Ombretta, Adami Silvano, Rossini Maurizio
Abstract excerpt
The anti-inflammatory actions of IL-4 are well established through earlier findings. However, the exact mechanism it uses to downregulate the pro-inflammatory cytokine production through monocytes and macrophages is poorly understood. In this study, we examined the effect of IL-4 in the induction of 11β-HSD1 in the two main classes of monocytes, CD14++ CD16- (CD14) and CD14+ CD16+ (CD16). Peripheral Blood...
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