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Article

Production of individualized V gene databases reveals high levels of immunoglobulin genetic diversity.

Nature communications - 20 Dec 2016

Corcoran Martin M, Phad Ganesh E, Vázquez Bernat Néstor, Stahl-Hennig Christiane, Sumida Noriyuki, Persson Mats A A, Martin Marcel, Karlsson Hedestam Gunilla B

Abstract excerpt

Comprehensive knowledge of immunoglobulin genetics is required to advance our understanding of B cell biology. Validated immunoglobulin variable (V) gene databases are close to completion only for human and mouse. We present a novel computational approach, IgDiscover, that identifies germline V genes from expressed repertoires to a specificity of 100%. IgDiscover uses a cluster identification process to produce...

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Identifiers

PMID: 27995928
DOI: 10.1038/ncomms13642
PMCID: PMC5187446

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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