Article
Excess polymorphisms in genes for membrane proteins in Plasmodium falciparum.
Science (New York, N.Y.) - 4 Oct 2002
Volkman Sarah K, Hartl Daniel L, Wirth Dyann F, Nielsen Kaare M, Choi Mehee, Batalov Serge, Zhou Yingyao, Plouffe David, Le Roch Karine G, Abagyan Ruben, Winzeler Elizabeth A
Abstract excerpt
The detection of single-nucleotide polymorphisms in pathogenic microorganisms has normally been carried out by trial and error. Here we show that DNA hybridization with high-density oligonucleotide arrays provides rapid and convenient detection of single-nucleotide polymorphisms in Plasmodium falciparum, despite its exceptionally high adenine-thymine (AT) content (82%). A disproportionate number of polymorphisms...
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