Article
XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactions.
The EMBO journal - 15 Nov 2001
Vidal A E, Boiteux S, Hickson I D, Radicella J P
Abstract excerpt
The major human AP endonuclease APE1 (HAP1, APEX, Ref1) initiates the repair of abasic sites generated either spontaneously, from attack of bases by free radicals, or during the course of the repair of damaged bases. APE1 therefore plays a central role in the base excision repair (BER) pathway. We report here that XRCC1, another essential protein involved in the maintenance of genome stability, physically...
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