Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The divergent N-terminal domain of Tim17 is critical for its assembly in the TIM complex in Trypanosoma brucei.

Molecular and biochemical parasitology - 1 Dec 2017

Weems Ebony, Singha Ujjal K, Smith Joseph T, Chaudhuri Minu

Abstract excerpt

Trypanosoma brucei Tim17(TbTim17), the single member of the Tim17/23/22 protein family, is an essential component of the translocase of the mitochondrial inner membrane (TIM). In spite of the conserved secondary structure, the primary sequence of TbTim17, particularly the N-terminal hydrophilic region, is significantly divergent. In order to understand the function of this region we expressed two N-terminal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Knock-In Techniques
Share to Gene Knockdown Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitochondrial Membranes

Share to Peptidyl Transferases

Share to Protein Domains

Share to Protein Multimerization

Share to Proteome

Share to Trypanosoma brucei brucei

Source

Open in PubMed Open full text

Identifiers

PMID: 28965880
DOI: 10.1016/j.molbiopara.2017.09.003
PMCID: PMC5926198

Genes

SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The divergent N-terminal domain of Tim17 is critical for its assembly in the TIM complex in Trypanosoma brucei.PMID 28965880Read ↗

Role of Tim17 Transmembrane Regions in Regulating the Architecture of Presequence Translocase and Mitochondrial DNA Stability.Semantic proximity Read ↗

Biogenesis of Tim23 and Tim17, integral components of the TIM machinery for matrix‐targeted preproteinsSemantic proximity Read ↗

Biogenesis of Tim Proteins of the Mitochondrial Carrier Import Pathway: Differential Targeting Mechanisms and Crossing Over with the Main Import PathwaySemantic proximity Read ↗

The Tim54p-Tim22p complex mediates insertion of proteins into the mitochondrial inner membrane.Semantic proximity Read ↗

Suppression of a defect in mitochondrial protein import identifies cytosolic proteins required for viability of yeast cells lacking mitochondrial DNA.Semantic proximity Read ↗

The Import of Proteins into the Mitochondrion of Toxoplasma gondiiSemantic proximity Read ↗

Hotspots for Disease-Causing Mutations in the Mitochondrial TIM23 Import Complex.Semantic proximity Read ↗

OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocaseSemantic proximity Read ↗

The channel-forming Sym1 protein is transported by the TIM23 complex in a presequence-independent manner.Semantic proximity Read ↗

Intramolecular disulfide bond of Tim22 protein maintains integrity of the TIM22 complex in the mitochondrial inner membrane.Semantic proximity Read ↗

InVivo Dissection of the Intrinsically Disordered Receptor Domain of Tim23.Semantic proximity Read ↗

Molecular and genetic analyses of Tic20 homologues in Arabidopsis thaliana chloroplasts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.