Article
Lung cancer in never smokers: molecular profiles and therapeutic implications.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2009
Rudin Charles M, Avila-Tang Erika, Harris Curtis C, Herman James G, Hirsch Fred R, Pao William, Schwartz Ann G, Vahakangas Kirsi H, Samet Jonathan M
Abstract excerpt
The majority of lung cancers are caused by long term exposure to the several classes of carcinogens present in tobacco smoke. Although a significant fraction of lung cancers in never smokers may also be attributable to tobacco, many such cancers arise in the absence of detectable tobacco exposure, and may follow a very different cellular and molecular pathway of malignant transformation. Recent studies summarized...
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