Article
Structural characterization of the α-mating factor prepro-peptide for secretion of recombinant proteins in Pichia pastoris.
Gene - 20 Jan 2017
Chahal Sabreen, Wei Peter, Moua Pachai, Park Sung Pil James, Kwon Janet, Patel Arth, Vu Anthony T, Catolico Jason A, Tsai Yu Fang Tina, Shaheen Nadia, Chu Tiffany T, Tam Vivian, Khan Zill-E-Huma, Joo Hyun Henry, Xue Liang, Lin-Cereghino Joan, Tsai Jerry W, Lin-Cereghino Geoff P
Abstract excerpt
The methylotrophic yeast Pichia pastoris has been used extensively for expressing recombinant proteins because it combines the ease of genetic manipulation, the ability to provide complex posttranslational modifications and the capacity for efficient protein secretion. The most successful and commonly used secretion signal leader in Pichia pastoris has been the alpha mating factor (MATα) prepro secretion signal....
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