Article
Clinical and genetic heterogeneity of amyotrophic lateral sclerosis.
Clinical genetics - 1 May 2013
Sabatelli M, Conte A, Zollino M
Abstract excerpt
Although clinical picture of amyotrophic lateral sclerosis (ALS) is a stereotypical one, resulting from combination of signs secondary to dysfunction of both upper motor neuron (UMN) and lower motor neuron (LMN), clinical heterogeneity is a consistent feature of the disease. Age of onset, relative mix of UMN and LMN signs, duration of the disease and association with other conditions are major factors...
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