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Article

The phenotypic variability of amyotrophic lateral sclerosis.

Nature reviews. Neurology - 1 Nov 2014

Swinnen Bart, Robberecht Wim

Abstract excerpt

Classic textbook neurology teaches that amyotrophic lateral sclerosis (ALS) is a degenerative disease that selectively affects upper and lower motor neurons and is fatal 3-5 years after onset--a description which suggests that the clinical presentation of ALS is very homogenous. However, clinical and postmortem observations, as well as genetic studies, demonstrate that there is considerable variability in the...

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Identifiers

PMID: 25311585
DOI: 10.1038/nrneurol.2014.184

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