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Article

Critical Function of PRDM2 in the Neoplastic Growth of Testicular Germ Cell Tumors

14 Dec 2016

Abstract excerpt

Testicular germ cell tumors (TGCTs) derive from primordial germ cells. Their maturation is blocked at different stages, reflecting histological tumor subtypes. A common genetic alteration in TGCT is a deletion of the chromosome 1 short arm, where the PRDM2 gene, belonging to the Positive Regulatory domain gene (PRDM) family, is located. Expression of PRDM2 gene is shifted in different human tumors, where the...

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PMID: 27983647
DOI: 10.3390/biology5040054

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