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Article

Deregulation of the RB pathway in human testicular germ cell tumours

3 Mar 2003

Abstract excerpt

Deregulation of the RB pathway is shared by most human malignancies. Components upstream of the retinoblastoma tumour suppressor (pRB), namely the INK4 family of cyclin-dependent kinase (CDK) inhibitors, the D-type cyclins, their partner kinases CDK4/CDK6, and pRB as their critical substrate, are differentially targeted in diverse types of cancer. An 'unorthodox' spectrum of defects within this cascade occurs in...

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PMID: 12754735
DOI: 10.1002/path.1353

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