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Article

Tumor Risk in Disorders of Sex Development

1 Jan 2010

Abstract excerpt

Certain patients with disorders of sex development (DSD), who bear Y chromosome material in their karyotype, are at increased risk for the development of type II germ cell tumors (GCT), which arise from early fetal germ cells. DSD gonads frequently harbor immature germ cells which express early fetal germ cell markers. Some of them (e.g. OCT3/4 and NANOG) seem to be of pathogenetic relevance in GCT development...

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PMID: 20558977
DOI: 10.1159/000314536

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