Article
Evolution of multiple cell clones over a 29-year period of a CLL patient.
Nature communications - 16 Dec 2016
Zhao Zhikun, Goldin Lynn, Liu Shiping, Wu Liang, Zhou Weiyin, Lou Hong, Yu Qichao, Tsang Shirley X, Jiang Miaomiao, Li Fuqiang, McMaster MaryLou, Li Yang, Lin Xinxin, Wang Zhifeng, Xu Liqin, Marti Gerald, Li Guibo, Wu Kui, Yeager Meredith, Yang Huanming, Xu Xun, Chanock Stephen J, Li Bo, Hou Yong, Caporaso Neil, Dean Michael
Abstract excerpt
Chronic lymphocytic leukaemia (CLL) is a frequent B-cell malignancy, characterized by recurrent somatic chromosome alterations and a low level of point mutations. Here we present single-nucleotide polymorphism microarray analyses of a single CLL patient over 29 years of observation and treatment, and transcriptome and whole-genome sequencing at selected time points. We identify chromosome alterations 13q14-, 6q-...
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