Article
Genomewide Association Study Identifies Novel Genetic Loci That Modify Antiplatelet Effects and Pharmacokinetics of Clopidogrel.
Clinical pharmacology and therapeutics - 1 Jun 2017
Zhong W-P, Wu H, Chen J-Y, Li X-X, Lin H-M, Zhang B, Zhang Z-W, Ma D-L, Sun S, Li H-P, Mai L-P, He G-D, Wang X-P, Lei H-P, Zhou H-K, Tang L, Liu S-W, Zhong S-L
Abstract excerpt
Genetic variants in the pharmacokinetic (PK) mechanism are the main underlying factors affecting the antiplatelet response to clopidogrel. Using a genomewide association study (GWAS) to identify new genetic loci that modify antiplatelet effects in Chinese patients with coronary heart disease, we identified novel variants in two transporter genes (SLC14A2 rs12456693, ATP-binding cassette [ABC]A1 rs2487032) and in...
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