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Article

Genome-wide analysis of clopidogrel active metabolite levels identifies novel variants that influence antiplatelet response.

Pharmacogenetics and genomics - 1 Apr 2017

Backman Joshua D, O'Connell Jeffrey R, Tanner Keith, Peer Cody J, Figg William D, Spencer Shawn D, Mitchell Braxton D, Shuldiner Alan R, Yerges-Armstrong Laura M, Horenstein Richard B, Lewis Joshua P

Abstract excerpt

Clopidogrel is one of the most commonly used therapeutics for the secondary prevention of cardiovascular events in patients with acute coronary syndromes. However, considerable interindividual variation in clopidogrel response has been documented, resulting in suboptimal therapy and an increased risk of recurrent events for some patients. In this investigation, we carried out the first genome-wide association...

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Source

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Identifiers

PMID: 28207573
DOI: 10.1097/FPC.0000000000000272
PMCID: PMC5346037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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