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Polymorphisms of genes related to phase II metabolism and resistance to clopidogrel.

Pharmacogenomics - 1 Jan 2022

Alkattan Abdullah, Alkhalifah Ahmed, Alsalameen Eman, Alghanim Fatimah, Radwan Nashwa

Abstract excerpt

Clopidogrel is an antiplatelet drug commonly used to prevent coagulation. This review aimed to investigate the effect of polymorphisms of G6PD, GCLC, GCLM, GSS, GST, GSR, HK and GLRX genes on clopidogrel during phase II metabolism through exploring previous studies. The results revealed that low glutathione plasma levels caused by several alleles related to these genes could affect the bioactivation process of...

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PMID: 34866404
DOI: 10.2217/pgs-2021-0092

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