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Article

CREBBP knockdown enhances RAS/RAF/MEK/ERK signaling in Ras pathway mutated acute lymphoblastic leukemia but does not modulate chemotherapeutic response.

Haematologica - 1 Apr 2017

Dixon Zach A, Nicholson Lindsay, Zeppetzauer Martin, Matheson Elizabeth, Sinclair Paul, Harrison Christine J, Irving Julie A E

Abstract excerpt

Relapsed acute lymphoblastic leukemia is the most common cause of cancer-related mortality in young people and new therapeutic strategies are needed to improve outcome. Recent studies have shown that heterozygous inactivating mutations in the histone acetyl transferase, CREBBP, are particularly frequent in relapsed childhood acute lymphoblastic leukemia and associated with a hyperdiploid karyotype and KRAS...

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Topics

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Share to Acetylation
Share to CREB-Binding Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to Gene Knockdown Techniques

Share to MAP Kinase Signaling System

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to ras Proteins

Share to Receptors, Glucocorticoid

Source

Open in PubMed Open full text

Identifiers

PMID: 27979926
DOI: 10.3324/haematol.2016.145177
PMCID: PMC5395114

Genes

CREBBP
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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