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Inhibiting H3K27 Demethylases Downregulates CREB ‐ CREBBP , Overcoming Resistance in Relapsed Acute Lymphoblastic Leukemia

1 Jan 2025

Abstract excerpt

BACKGROUND: CREB binding protein (CREBBP) is a key epigenetic regulator, altered in a fifth of relapsed cases of acute lymphoblastic leukemia (ALL). Selectively targeting epigenetic signaling may be an effective novel therapeutic approach to overcome drug resistance. Anti-tumor effects have previously been demonstrated for GSK-J4, a selective H3K27 histone demethylase inhibitor, in several animal models of...

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PMID: 39791538
DOI: 10.1002/cam4.70596

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