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Article

BMI-1 extends proliferative potential of human bronchial epithelial cells while retaining their mucociliary differentiation capacity.

American journal of physiology. Lung cellular and molecular physiology - 1 Feb 2017

Munye Mustafa M, Shoemark Amelia, Hirst Robert A, Delhove Juliette M, Sharp Tyson V, McKay Tristan R, O'Callaghan Christopher, Baines Deborah L, Howe Steven J, Hart Stephen L

Abstract excerpt

Air-liquid interface (ALI) culture of primary airway epithelial cells enables mucociliary differentiation providing an in vitro model of the human airway, but their proliferative potential is limited. To extend proliferation, these cells were previously transduced with viral oncogenes or mouse Bmi-1 + hTERT, but the resultant cell lines did not undergo mucociliary differentiation. We hypothesized that use of...

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Identifiers

PMID: 27979861
DOI: 10.1152/ajplung.00471.2016
PMCID: PMC5336581

Genes

DNAH5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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