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Article

Modelling of primary ciliary dyskinesia using patient-derived airway organoids.

EMBO reports - 6 Dec 2021

van der Vaart Jelte, Böttinger Lena, Geurts Maarten H, van de Wetering Willine J, Knoops Kèvin, Sachs Norman, Begthel Harry, Korving Jeroen, Lopez-Iglesias Carmen, Peters Peter J, Eitan Kerem, Gileles-Hillel Alex, Clevers Hans

Abstract excerpt

Patient-derived human organoids can be used to model a variety of diseases. Recently, we described conditions for long-term expansion of human airway organoids (AOs) directly from healthy individuals and patients. Here, we first optimize differentiation of AOs towards ciliated cells. After differentiation of the AOs towards ciliated cells, these can be studied for weeks. When returned to expansion conditions, the...

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Identifiers

PMID: 34693619
DOI: 10.15252/embr.202052058
PMCID: PMC8647008

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