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Article

Preclinical human models of primary ciliary dyskinesia.

European respiratory review : an official journal of the European Respiratory Society - 1 Jul 2026

Ong Jonathan W Y, Jackson Claire L, Arbi Marina, Hart Stephen L, Mill Pleasantine, Paff Tamara, Rubbo Bruna, Shahaj Eriomina, Shoemark Amelia, Lucas Jane S

Abstract excerpt

Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder caused by defective motile cilia, resulting in impaired mucociliary clearance, chronic respiratory disease, laterality defects and subfertility. Currently, no disease-modifying treatments exist. Targeting PCD at its root cause requires emerging genetic therapies, such as small molecules, oligonucleotides, mRNA therapy, gene replacement and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42386312
DOI: 10.1183/16000617.0334-2025
PMCID: PMC13320625

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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