Article

Primary Ciliary Dyskinesia patient specific hiPSC-derived airway epithelium in Air Liquid Interface culture recapitulates disease specific phenotypes <i>in vitro</i>

2023-04-25

Abstract excerpt

Primary ciliary dyskinesia (PCD) is a rare heterogenic genetic disorder associated with perturbed biogenesis or function of motile cilia. Motile cilia dysfunction results in diminished mucociliary clearance (MCC) of pathogens in the respiratory tract and chronic airway inflammation and infections successively causing progressive lung damage. Current approaches to treat PCD are symptomatic, only, indicating an urge...

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Literature Corpus work: 9b1e09e1-10a7-5ada-b2ca-4293aa5f2022
DOI: 10.1101/2023.04.25.538316

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