Article
Cytotoxic T Cells and Granzyme B Associated with Improved Colorectal Cancer Survival in a Prospective Cohort of Older Women.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Apr 2017
Prizment Anna E, Vierkant Robert A, Smyrk Thomas C, Tillmans Lori S, Nelson Heather H, Lynch Charles F, Pengo Thomas, Thibodeau Stephen N, Church Timothy R, Cerhan James R, Anderson Kristin E, Limburg Paul J
Abstract excerpt
Background: Host immune response may predict the course of colorectal cancer. We examined the survival of 468 colorectal cancer patients associated with two tumor-infiltrating immune biomarkers, the number of cytotoxic T lymphocytes (CTLs), and the activated CTLs, as reflected by the number of cells expressing granzyme B (GZMB) in the prospective Iowa Women's Health Study.Methods: Using paraffin-embedded tissue...
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