Article
Granzyme B PET Imaging of Immune Checkpoint Inhibitor Combinations in Colon Cancer Phenotypes.
Molecular imaging and biology - 1 Oct 2020
Goggi J L, Tan Y X, Hartimath S V, Jieu B, Hwang Y Y, Jiang L, Boominathan R, Cheng P, Yuen T Y, Chin H X, Tang J R, Larbi A, Chacko A M, Renia L, Johannes C, Robins Edward G
Abstract excerpt
PURPOSE: Immune checkpoint inhibitor (ICI) monotherapy and combination regimens are being actively pursued as strategies to improve durable response rates in cancer patients. However, the biology surrounding combination therapies is not well understood and may increase the likelihood of immune-mediated adverse events. Accurate stratification of ICI response by non-invasive PET imaging may help ensure safe therapy...
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