Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury.

doi:10.1016/j.chembiol.2021.04.001

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Article

Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury.

Cell chemical biology - 16 Sept 2021

Larraufie Marie-Hélène, Gao Xiaolin, Xia Xiaobo, Devine Patrick J, Kallen Joerg, Liu Dong, Michaud Gregory, Harsch Andreas, Savage Nik, Ding Jian, Tan Kian, Mihalic Manuel, Roggo Silvio, Canham Stephen M, Bushell Simon M, Krastel Philipp, Gao Jinhai, Izaac Aude, Altinoglu Erhan, Lustenberger Philipp, Salcius Michael, Harbinski Fred, Williams Eric T, Zeng Liling, Loureiro Joseph, Cong Feng, Fryer Christy J, Klickstein Lloyd, Tallarico John A, Jain Rishi K, Rothman Deborah M, Wang Shaowen

Abstract excerpt

Acute kidney injury (AKI) is a life-threatening disease with no known curative or preventive therapies. Data from multiple animal models and human studies have linked dysregulation of bone morphogenetic protein (BMP) signaling to AKI. Small molecules that potentiate endogenous BMP signaling should have a beneficial effect in AKI. We performed a high-throughput phenotypic screen and identified a series of FK506...

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PMID: 33894161
DOI: 10.1016/j.chembiol.2021.04.001

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