Article
PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma.
PLoS genetics - 1 Dec 2016
Pytel Dariusz, Gao Yan, Mackiewicz Katarzyna, Katlinskaya Yuliya V, Staschke Kirk A, Paredes Maria C G, Yoshida Akihiro, Qie Shuo, Zhang Gao, Chajewski Olga S, Wu Lawrence, Majsterek Ireneusz, Herlyn Meenhard, Fuchs Serge Y, Diehl J Alan
Abstract excerpt
The unfolded protein response (UPR) regulates cell fate following exposure of cells to endoplasmic reticulum stresses. PERK, a UPR protein kinase, regulates protein synthesis and while linked with cell survival, exhibits activities associated with both tumor progression and tumor suppression. For example, while cells lacking PERK are sensitive to UPR-dependent cell death, acute activation of PERK triggers both...
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