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A T7 Endonuclease I Assay to Detect Talen-Mediated Targeted Mutation of HBV cccDNA.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017

Bloom Kristie, Ely Abdullah, Arbuthnot Patrick

Abstract excerpt

Gene editing using designer nucleases is now widely used in many fields of molecular biology. The technology is being developed for the treatment of viral infections such as persistant hepatitis B virus (HBV). The replication intermediate of HBV comprising covalently closed circular DNA (cccDNA) is stable and resistant to available licensed antiviral agents. Advancing gene editing as a means of introducing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27975310
DOI: 10.1007/978-1-4939-6700-1_8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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