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Article

Channel-Inactivating Mutations and Their Revertant Mutants in the Envelope Protein of Infectious Bronchitis Virus.

Journal of virology - 1 Mar 2017

To Janet, Surya Wahyu, Fung To Sing, Li Yan, Verdià-Bàguena Carmina, Queralt-Martin Maria, Aguilella Vicente M, Liu Ding Xiang, Torres Jaume

Abstract excerpt

It has been shown previously in the severe acute respiratory syndrome coronavirus (SARS-CoV) that two point mutations, N15A and V25F, in the transmembrane domain (TMD) of the envelope (E) protein abolished channel activity and led to in vivo attenuation. Pathogenicity was recovered in mutants that also regained E protein channel activity. In particular, V25F was rapidly compensated by changes at multiple...

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Identifiers

PMID: 27974570
DOI: 10.1128/JVI.02158-16
PMCID: PMC5309962

Genes

EMD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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