Article
The Genetic Stability, Replication Kinetics and Cytopathogenicity of Recombinant Avian Coronaviruses with a T16A or an A26F Mutation within the E Protein Is Cell-Type Dependent.
Viruses - 15 Aug 2022
Webb Isobel, Keep Sarah, Littolff Kieran, Stuart Jamie, Freimanis Graham, Britton Paul, Davidson Andrew D, Maier Helena J, Bickerton Erica
Abstract excerpt
The envelope (E) protein of the avian coronavirus infectious bronchitis virus (IBV) is a small-membrane protein present in two forms during infection: a monomer and a pentameric ion channel. Each form has an independent role during replication; the monomer disrupts the secretory pathway, and the pentamer facilitates virion production. The presence of a T16A or A26F mutation within E exclusively generates the...
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