Article
Analysis of the equalization of inverted repeats and neurovirulence using a pseudorabies virus mutant strain altered at the Ul/Ir junction.
Virus genes - 1 Jan 1998
Boldogköi Z, Braun A, Medveczky I, Glávits R, Gyúró B, Fodor I
Abstract excerpt
A recombinant pseudorabies (Aujeszky's disease) virus (PrV) designated as vE16lac was constructed by deleting a 3-kbp DNA segment spanning the junction of long and short components of the viral genome, and by replacing the deleted segment with a lacZ-expression cassette. The aim of constructing t...
Topics
- Animals
- Cell Line
- Cloning, Molecular
- DNA, Viral
- Genes, Immediate-Early
- Herpesvirus 1, Suid
- Mice
- Mutagenesis, Site-Directed
- Mutation
- Recombination, Genetic
- Repetitive Sequences, Nucleic Acid
- Swine
- Virulence
- Virus Replication