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Article

The lysine methyltransferase Ehmt2/G9a is dispensable for skeletal muscle development and regeneration.

Skeletal muscle - 1 Jan 2016

Zhang Regan-Heng, Judson Robert N, Liu David Y, Kast Jürgen, Rossi Fabio M V

Abstract excerpt

BACKGROUND: Euchromatic histone-lysine N-methyltransferase 2 (G9a/Ehmt2) is the main enzyme responsible for the apposition of H3K9 di-methylation on histones. Due to its dual role as an epigenetic regulator and in the regulation of non-histone proteins through direct methylation, G9a has been implicated in a number of biological processes relevant to cell fate control. Recent reports employing in vitro cell lines...

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Identifiers

PMID: 27239264
DOI: 10.1186/s13395-016-0093-7
PMCID: PMC4882833

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