Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease.

The New England journal of medicine - 15 Dec 2016

Khera Amit V, Emdin Connor A, Drake Isabel, Natarajan Pradeep, Bick Alexander G, Cook Nancy R, Chasman Daniel I, Baber Usman, Mehran Roxana, Rader Daniel J, Fuster Valentin, Boerwinkle Eric, Melander Olle, Orho-Melander Marju, Ridker Paul M, Kathiresan Sekar

Abstract excerpt

BACKGROUND: Both genetic and lifestyle factors contribute to individual-level risk of coronary artery disease. The extent to which increased genetic risk can be offset by a healthy lifestyle is unknown. METHODS: Using a polygenic score of DNA sequence polymorphisms, we quantified genetic risk for coronary artery disease in three prospective cohorts - 7814 participants in the Atherosclerosis Risk in Communities...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cohort Studies
Share to Coronary Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cross-Sectional Studies

Share to Healthy Lifestyle

Share to Incidence

Share to Multifactorial Inheritance

Share to Patient Compliance

Source

Open in PubMed Open full text

Identifiers

PMID: 27959714
DOI: 10.1056/NEJMoa1605086
PMCID: PMC5338864

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease.PMID 27959714Read ↗

Genetic Risk, Adherence to a Healthy Lifestyle, and Ischemic Heart DiseaseSemantic proximity Read ↗

Adherence to a healthy lifestyle, genetic susceptibility to abdominal obesity, cardiometabolic risk markers, and risk of coronary heart disease.Semantic proximity Read ↗

Polygenic risk, lifestyle, and cardiovascular mortality: a prospective population-based UK Biobank studySemantic proximity Read ↗

Lifestyle factors, genetic susceptibility to obesity and their interactions on coronary artery disease risk: A cohort study in the UK Biobank.Semantic proximity Read ↗

Associations of genetic susceptibility and healthy lifestyle with incidence of coronary heart disease and stroke in individuals with hypertension.Semantic proximity Read ↗

Associations of Blood Lipid-Related Polygenic Scores, Lifestyle Factors and Their Combined Effects with Risk of Coronary Artery Disease in the UK Biobank Cohort.Semantic proximity Read ↗

Genetic Factors, Adherence to Healthy Lifestyle Behavior, and Risk of Invasive Breast Cancer Among Women in the UK Biobank.Semantic proximity Read ↗

Polygenic Risk, Lifestyle, and Cardiovascular Mortality: A Prospective UK Biobank StudySemantic proximity Read ↗

Genetic Risk, Healthy Lifestyle Adherence, and Risk of Developing Diabetes in the Japanese Population.Semantic proximity Read ↗

American Heart Association's Life's Simple 7: Lifestyle Recommendations, Polygenic Risk, and Lifetime Risk of Coronary Heart Disease.Semantic proximity Read ↗

Polygenic Risk Score Modifies Risk of Coronary Artery Disease Conferred by Low-Density Lipoprotein CholesterolSemantic proximity Read ↗

Genetic risk, adherence to a healthy lifestyle, and type 2 diabetes risk among 550,000 Chinese adults: results from 2 independent Asian cohorts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.