Article
A General Mechanism for the Propagation of Mutational Effects in Proteins.
Biochemistry - 10 Jan 2017
Rajasekaran Nandakumar, Suresh Swaathiratna, Gopi Soundhararajan, Raman Karthik, Naganathan Athi N
Abstract excerpt
Mutations in the hydrophobic interior of proteins are generally thought to weaken the interactions only in their immediate neighborhood. This forms the basis of protein engineering-based studies of folding mechanism and function. However, mutational work on diverse proteins has shown that distant residues are thermodynamically coupled, with the network of interactions within the protein acting as signal conduits,...
Topics
- Algorithms
- Animals
- Humans
- Hydrophobic and Hydrophilic Interactions
- Kinetics
- Molecular Dynamics Simulation
- Mutation
- Protein Domains
- Protein Stability
- Proteins
- Thermodynamics