Article
DNA polymerase β contains a functional nuclear localization signal at its N-terminus.
Nucleic acids research - 28 Feb 2017
Kirby Thomas W, Gassman Natalie R, Smith Cassandra E, Zhao Ming-Lang, Horton Julie K, Wilson Samuel H, London Robert E
Abstract excerpt
DNA polymerase β (pol β) requires nuclear localization to fulfil its DNA repair function. Although its small size has been interpreted to imply the absence of a need for active nuclear import, sequence and structural analysis suggests that a monopartite nuclear localization signal (NLS) may reside in the N-terminal lyase domain. Binding of this domain to Importin α1 (Impα1) was confirmed by gel filtration and NMR...
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