Article
Pyrazinamide susceptibility testing: proposed new standard with the BACTECTM MGITTM 960 system.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease - 1 Dec 2016
Piersimoni C, Mustazzolu A, Iacobino A, Giannoni F, Santoro G, Gherardi G, Del Giudice A, Perna R, Fattorini L
Abstract excerpt
The susceptibility of 253 Mycobacterium tuberculosis complex isolates to pyrazinamide (PZA) was assessed using the BACTECTM MGITTM 960 (M960) system. Resistant strains underwent paired repeat testing using 1) a critical concentration of 200 g/ml (PZA-200), and 2) a reduced inoculum of 0.25 ml. They were also examined using the BACTEC 460 (B460) reference method and investigated for pncA mutations. On M960, 37...
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