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Article

Determination of a Screening Metric for High Diversity DNA Libraries.

PloS one - 1 Jan 2016

Guido Nicholas J, Handerson Steven, Joseph Elaine M, Leake Devin, Kung Li A

Abstract excerpt

The fields of antibody engineering, enzyme optimization and pathway construction rely increasingly on screening complex variant DNA libraries. These highly diverse libraries allow researchers to sample a maximized sequence space; and therefore, more rapidly identify proteins with significantly improved activity. The current state of the art in synthetic biology allows for libraries with billions of variants,...

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PMID: 27930689
DOI: 10.1371/journal.pone.0167088
PMCID: PMC5145166

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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