Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondria regulate the cell fate decisions of megakaryocyte-erythroid progenitors.

Stem cell reports - 9 Dec 2025

Sung Eunkyu, Murakami Shohei, Morita Masanobu, Ida Tomoaki, Akaike Takaaki, Motohashi Hozumi

Abstract excerpt

Recent studies highlight the critical role of mitochondria in hematopoiesis, especially in stem cell function and erythroid maturation. To explore mitochondrial contributions to cell lineage commitment of hematopoietic progenitors, we utilized Cars2-mutant mice, an ideal model for this purpose. CARS2, a mitochondrial isoform of cysteinyl-tRNA synthetase, has cysteine persulfide synthase (CPERS) activity. Our new...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Differentiation
Share to Cell Lineage
Share to Megakaryocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mitochondria

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 41270746
DOI: 10.1016/j.stemcr.2025.102720
PMCID: PMC12744859

Genes

CARS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondria regulate the cell fate decisions of megakaryocyte-erythroid progenitors.PMID 41270746Read ↗

Mitochondria in hematopoiesis and hematological diseases.Semantic proximity Read ↗

Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunctionSemantic proximity Read ↗

The mitochondrial respiratory chain is essential for haematopoietic stem cell function.Semantic proximity Read ↗

Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype.Semantic proximity Read ↗

MtDNA mutagenesis impairs elimination of mitochondria during erythroid maturation leading to enhanced erythrocyte destruction.Semantic proximity Read ↗

Screen for abnormal mitochondrial phenotypes in mouse embryonic stem cells identifies a model for succinyl-CoA ligase deficiency and mtDNA depletion.Semantic proximity Read ↗

The mito::mKate2 mouse: A far-red fluorescent reporter mouse line for tracking mitochondrial dynamics in vivo.Semantic proximity Read ↗

A Conserved Role for Asrij/OCIAD1 in Progenitor Differentiation and Lineage Specification Through Functional Interaction With the Regulators of Mitochondrial DynamicsSemantic proximity Read ↗

An Essential Role for ECSIT in Mitochondrial Complex I Assembly and Mitophagy in MacrophagesSemantic proximity Read ↗

Rac2-MRC-cIII–generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitorsSemantic proximity Read ↗

Mitochondria in stem cells.Semantic proximity Read ↗

The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron–sulfur cluster biogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.